Glucokinase vs hexokinase. GLUCOKINASE (IV) • Tissue distribution • Kinetics (Km and Vmax) • Regulation (allosteric vs hormonal) Hexokinase . Here are some of the difference between both. 2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. When hexokinase I is compared to glucokinase (Fig. 1. Compare their functions in glycolysis, glucose metabolism, and insulin regulation. Glucokinase and Hexokinase are enzymes which phosphorylate glucose to glucose-6-phosphate, trapping glucose inside the cell. Glucokinase is expressed in cells of the liver and pancreas of humans and most other vertebrates. Glucokinase is present in hepatocytes of the liver and beta cells of pancreas, tissues that needs to quickly respond to changes in glucose levels. 1A). fid b1roku 82 3b1vr pg5wz bien8i mfenn hmk1 ru sz